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⏱️ 300s
🌱 Beginner Level — 0 / 60

Oropharyngeal Cancer — Systemic Therapy (Advanced)
A 59-year-old man with metastatic HPV-positive oropharyngeal squamous cell carcinoma. ECOG 1. PD-L1 CPS = 25.
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sfx_miss_firm
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sfx_correct_minimal
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sfx_complete_fanfare
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💡 Hint: Correct order adjusted to match available steps.
Cetuximab-based regimens if IO contraindicated
Pembrolizumab monotherapy if CPS ≥20 and low disease burden
Pembrolizumab + platinum/5-FU if symptomatic or high burden
Avoid upfront chemo alone without IO in PD-L1+ disease
Nivolumab or pembrolizumab if not used first-line
Check PD-L1 CPS score
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