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⏱️ 300s

🌱 Beginner Level — 0 / 60

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Oropharyngeal Cancer — Systemic Therapy (Advanced)

A 59-year-old man with metastatic HPV-positive oropharyngeal squamous cell carcinoma. ECOG 1. PD-L1 CPS = 25.

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💡 Hint: Correct order adjusted to match available steps.

Cetuximab-based regimens if IO contraindicated

Pembrolizumab monotherapy if CPS ≥20 and low disease burden

Pembrolizumab + platinum/5-FU if symptomatic or high burden

Avoid upfront chemo alone without IO in PD-L1+ disease

Nivolumab or pembrolizumab if not used first-line

Check PD-L1 CPS score

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