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Eduovisual

Behavioral Health

Suicide risk assessment and safety planning

Clinical Overview and When to Suspect Elevated Suicide Risk

— Suicide is a top-10 cause of death in the US; rates highest in middle-aged and elderly white men, AI/AN populations, and adolescents/young adults

— Firearms account for ~50% of completed suicides; lethal means access is the single most modifiable risk factor

— ~45% of completed suicides saw a primary care provider within 1 month of death — screening in PCP and ED settings is high-yield

— Any new or worsening depression, bipolar depression, schizophrenia, PTSD, borderline personality disorder, anorexia, or substance use disorder

— Recent psychiatric hospitalization (highest risk in first 30–90 days post-discharge)

— Acute psychosocial losses: job, relationship, legal trouble, financial crisis, recent humiliation

— Chronic pain, terminal illness, TBI, Huntington disease, MS

— New SSRI start in patients <25 (FDA black box for suicidal ideation, not completions)

PHQ-9 item 9 as universal screen in primary care (USPSTF: screen all adults and adolescents 12+ for depression with systems to ensure follow-up)

— Positive screen → administer Columbia Suicide Severity Rating Scale (C-SSRS) or ASQ (Ask Suicide-Screening Questions) for stratification

— Screen separates ideation (passive vs active), intent, plan, and preparatory behavior

— Step 3 vignettes commonly test the outpatient clinician's next step after a positive PHQ-9, the ED disposition decision, and post-discharge follow-up cadence

— Expect questions on lethal means counseling, safety planning vs no-suicide contracts, and involuntary hold criteria

Step 3 management: Asking directly about suicide does not increase risk — this myth is a frequent distractor. Every positive depression screen requires a direct, specific suicide inquiry documented in the note, followed by structured risk stratification before disposition.

Scope of the problem
When to actively assess risk
Recommended screening tools
Step 3 framing
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Presentation Patterns and Key History

— "I want to die," "Everyone would be better off without me," "I won't be here much longer"

— Passive ideation ("I wish I wouldn't wake up") still requires full assessment — can escalate

— Indirect: giving away possessions, sudden goodbyes, finalizing wills, unexplained calm after prolonged depression (ominous — may indicate decision made)

Sex (male — higher completion), Age (<19 or >45), Depression

Previous attempt (strongest single predictor — 5–6× risk), Ethanol/substance use, Rational thought loss (psychosis), Social supports lacking, Organized plan, No spouse, Sickness

Ideation: frequency, duration, controllability, passive vs active

Plan: method, specificity, lethality, rehearsal

Intent: subjective ("Do you intend to act?") and behavioral (preparatory acts)

Access to means: firearms in home (ask explicitly), stockpiled medications, ropes, high places

Prior attempts: method, lethality, medical consequences, rescue circumstances, ambivalence, regret about surviving

Protective factors: children at home, religious objection, future-oriented plans, therapeutic alliance, sobriety

— With patient consent ideally, but HIPAA permits gathering (not disclosing) collateral in emergencies

— Speak to family/partner about firearm access, medication stockpiling, recent behavior changes

Board pearl: A patient who downplays prior attempts ("It wasn't really serious") but had medically severe consequences or took precautions against discovery is at higher, not lower, risk. Lethality of prior attempt + low rescue probability = high future risk, regardless of stated intent.

Key distinction: Non-suicidal self-injury (NSSI) — cutting, burning for affect regulation, no intent to die — is distinct from suicide attempt, but NSSI patients still have elevated long-term suicide risk and require assessment.

Direct verbal cues
SAD PERSONS / acute risk factors (memorize)
History elements to elicit (chronological)
Collateral information
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Mental Status Exam and Clinical Assessment

— Disheveled grooming, poor eye contact, psychomotor retardation (severe depression) vs agitation (mixed states, akathisia — akathisia is independently linked to suicide)

— Look for self-inflicted wounds (wrists, forearms, thighs), ligature marks, healed scars suggesting prior NSSI or attempts

— Intoxication signs: alcohol on breath, pupillary changes, ataxia — acute intoxication markedly raises near-term risk and impairs assessment reliability

— Hopelessness is the single cognitive predictor most strongly correlated with completed suicide — assess with Beck Hopelessness Scale concepts: "Can you imagine things getting better?"

— Anhedonia, anergia, guilt, worthlessness

— Watch for sudden brightening after persistent depression — may signal resolved ambivalence after deciding to act

— Command auditory hallucinations to harm self (schizophrenia, severe MDD with psychotic features) — high acuity

— Delusions of guilt, poverty, nihilism (Cotard) — elevate risk

— Ruminative, constricted thinking; inability to generate alternatives ("tunnel vision")

— Assess for delirium or dementia that could impair safety judgment

— Insight into illness and willingness to engage in treatment is itself a protective factor

— Vitals (overdose, hemodynamic compromise)

— Skin survey for wounds; neck for ligature; abdomen for ingestion tenderness

— Toxicology screen, acetaminophen/salicylate levels, ethanol, EKG (QTc — affects antidepressant choice and screens for TCA ingestion)

CCS pearl: On CCS, a suicidal patient in the ED requires immediate orders for 1:1 sitter, search/removal of belongings (belts, shoelaces, sharps), and toxicology workup before disposition decisions. Document MSE explicitly — risk stratification without MSE is incomplete.

Appearance and behavior
Mood and affect
Thought process and content
Cognition and insight
Physical assessment when indicated
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Diagnostic Workup — Initial Labs and Toxicology

CBC, BMP — baseline, electrolyte derangements from ingestion or self-neglect

LFTs — acetaminophen toxicity, chronic alcohol use

Acetaminophen and salicylate levels in ALL intentional overdoses (occult co-ingestion is common and treatable; measure at 4 hours post-ingestion for APAP, plot on Rumack-Matthew nomogram)

Urine drug screen (limitations: doesn't detect synthetic opioids, GHB, many benzodiazepines)

Ethanol level — quantify, do not just qualitative

Urine pregnancy (β-hCG) in females of reproductive age — affects pharmacology and disposition

TSH — hypo/hyperthyroidism mimicking depression

EKG — QTc baseline, TCA ingestion (wide QRS, terminal R in aVR), citalopram overdose

Lithium level if on lithium — therapeutic window narrow, overdose common

VPA, carbamazepine, digoxin, TCA levels as indicated

Carboxyhemoglobin if suspected CO inhalation (suicide in enclosed space, vehicle exhaust)

ABG/VBG with anion gap — toxic alcohols, salicylates, metformin

CK, myoglobin, UA — rhabdomyolysis after prolonged down-time

CT head if AMS, anticoagulated, fall, head trauma, suspected TBI in attempt

CT chest/abdomen for ingestion of caustics, foreign bodies, button batteries (peds)

CXR for aspiration after ingestion or hanging attempts

— Capacity is decision-specific and time-specific — a patient may lack capacity to refuse psychiatric admission but retain capacity for other choices

— Document the four elements: communicate choice, understand information, appreciate situation, reason about options

Board pearl: Always check acetaminophen level regardless of stated ingestion — APAP is the most common occult co-ingestant, is clinically silent for 24–48 hours, and N-acetylcysteine is highly effective if started within 8 hours. Missing this is a classic Step 3 error and a real-world cause of preventable death.

Universal ED labs for suicidal patient or post-attempt
Targeted labs
Imaging
Capacity/decisional assessment
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Structured Risk Stratification and the Suicide Risk Formulation

— Modern practice (per VA/DoD, Joint Commission, Zero Suicide framework) replaces rigid scales with a structured clinical judgment that integrates static and dynamic factors

Static (chronic) risk: prior attempts, family history of suicide, chronic psychiatric illness, history of trauma/abuse, chronic medical illness, male sex

Dynamic (acute) risk: current ideation/intent/plan, hopelessness, recent loss, intoxication, insomnia, agitation, access to means, recent discharge

Protective factors: treatment engagement, social support, dependents, religious belief, future orientation, problem-solving ability

High acute risk: ideation + plan + intent + means + impaired judgment → inpatient psychiatric admission (voluntary preferred; involuntary if refuses and meets criteria)

Intermediate acute risk: active ideation without specific plan/intent, with concerning dynamic factors → intensive outpatient, partial hospitalization, or admission case-by-case; mandatory safety planning, means restriction, 24–72 hr follow-up

Low acute risk: passive ideation, no plan/intent, robust protective factors → outpatient management with safety plan, lethal means counseling, close follow-up

— Specific ideation/plan/intent description, risk and protective factors, formulation ("In summary, this patient is at intermediate acute / chronic high risk because…"), disposition rationale, safety plan, follow-up

No-suicide "contracts" are not evidence-based and do not reduce risk or provide legal protection — replaced by Stanley-Brown Safety Planning Intervention

— No tool reliably predicts individual suicide; the goal is risk reduction, not prediction

— Even high-risk patients on inpatient units complete suicide — vigilance is continuous

Key distinction: Risk assessment is the snapshot stratification; safety planning is the active intervention. Both are required at every encounter where suicidal ideation is identified — Step 3 stems may offer "obtained safety plan" without assessment, or vice versa, as wrong answers.

Beyond checklists — clinical risk formulation
Tiered acuity
Documentation essentials
Predictive limits
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First-Line Management Logic — Disposition Decision Tree

— Remove access to means in the assessment environment: belts, shoelaces, sharps, plastic bags, cords

1:1 continuous observation for any patient with active suicidal ideation in ED

— Treat acute medical issues (overdose, trauma) first; medical clearance before psychiatric disposition

Inpatient psychiatric admission indicated for:

— Active intent or plan with means

— Recent attempt with ongoing intent or severe lethality

— Command hallucinations to self-harm

— Severe depression with psychosis or catatonia

— Inability to maintain safety as outpatient (no support, intoxication, severe agitation)

Voluntary admission preferred — preserves alliance, autonomy

Involuntary hold (varies by state — e.g., 72-hour 5150 in CA, 2PC in NY) when patient meets criteria (danger to self/others due to mental illness) and refuses voluntary care

Stanley-Brown Safety Plan completed collaboratively (see chunk 7 detail)

Lethal means counseling — specific firearm and medication restriction

Follow-up within 24–72 hours (phone or in-person)

Crisis resources: 988 Suicide & Crisis Lifeline, Crisis Text Line, local mobile crisis

— Engage family/support person with patient consent

— Treat underlying disorder (MDD, bipolar, SUD, psychosis)

— Consider augmentation: lithium (anti-suicide effect in mood disorders), clozapine (FDA-approved for schizophrenia suicide reduction), ketamine for acute ideation

Step 3 management: The single most evidence-based intervention to reduce suicide death is means restriction, particularly firearm access. A patient discharged with active depression and a firearm at home is high-risk regardless of safety plan completion — counsel for off-site storage (relative, gun shop, police), gun locks, or voluntary surrender. Document the counseling and the patient's plan.

Step 1: Ensure immediate physical safety
Step 2: Determine acuity and disposition
Step 3: If discharged, mandatory components
Step 4: Initiate or adjust treatment
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Pharmacotherapy and Stanley-Brown Safety Planning

1. Warning signs: personal triggers, thoughts, situations that precede crisis

2. Internal coping strategies: distraction, exercise, music — without contacting others

3. Social contacts and settings for distraction (not necessarily disclosing crisis)

4. People to contact for help: family/friends who know and can support

5. Professionals and agencies: therapist, psychiatrist, 988, ED

6. Means restriction plan: specific, written, named third party for firearms/meds

— Co-created with patient, written legibly, copy to patient, copy in chart, share with family if consented

Lithium — reduces suicide and all-cause mortality in bipolar disorder and recurrent MDD; strongest anti-suicide evidence of any psychotropic; target 0.6–1.0 mEq/L; monitor TSH, Cr, levels

Clozapine — FDA-approved to reduce suicidality in schizophrenia/schizoaffective disorder; requires ANC monitoring (REMS program)

Ketamine/esketamine (Spravato) — rapid reduction of suicidal ideation within hours; intranasal esketamine FDA-approved for MDD with acute suicidality; observe 2 hours post-dose (sedation, BP, dissociation)

ECT — fastest definitive treatment for severe depression with active suicidality, catatonia, psychotic depression; works within 1–2 weeks

— FDA black box: increased suicidal ideation (not completion) in patients <25, particularly first 4 weeks

— Do not withhold SSRI in young adult with MDD — untreated depression carries higher suicide risk; instead, monitor closely (weekly × 4 weeks, then biweekly)

— Avoid abrupt discontinuation; favor sertraline, fluoxetine, escitalopram for safety in overdose

Avoid TCAs and MAOIs as first-line in suicidal patients — lethal in overdose

Board pearl: Among antidepressants, TCAs cause the most overdose deaths per prescription. If a TCA is needed, dispense in limited 1-week supplies to a suicidal patient and avoid amitriptyline/doxepin (highest lethality). SSRIs are far safer in overdose.

Stanley-Brown Safety Planning Intervention (6 steps)
Pharmacotherapy with anti-suicidal evidence
SSRIs and the black box
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Crisis Interventions and Means Restriction — Operational Details

Firearms (50% of US suicide deaths, 85% case fatality):

— Ask: "Are there firearms in the home or accessible to you?"

— Options in order of effectiveness: temporary off-site storage with trusted party, gun shop/range storage, law enforcement hold, voluntary disposal, in-home locking with ammunition stored separately

Extreme Risk Protection Orders (ERPOs/red flag laws) — available in many states; allow temporary firearm removal via court order; physicians may petition in some states

Medications:

— Limit dispensing quantities; blister packs; lock boxes

— Remove TCAs, opioids, benzodiazepines, acetaminophen stockpiles

— Family member dispenses daily doses

Other means: secure ropes/cords, address access to bridges/heights, vehicle exhaust prevention

988 Suicide & Crisis Lifeline — universal US number, 24/7, with chat and text

Mobile crisis teams — co-response with mental health professionals (not police-only)

Crisis stabilization units / 23-hour observation — alternative to inpatient for intermediate-risk patients

Partial hospitalization / intensive outpatient (PHP/IOP) — step-down or step-up

— Environmental: ligature-resistant fixtures, breakaway shower rods, weighted/anchored furniture, tamper-resistant outlets, no plastic bags

— Q15-minute checks at minimum; 1:1 for highest acuity

— Contraband searches on admission and after visits

Highest inpatient suicide risk: bathrooms, bedrooms during shift change, weekend nights, time of pass/discharge

Cognitive Therapy for Suicide Prevention (CT-SP) — 50% reduction in repeat attempts

Dialectical Behavior Therapy (DBT) — borderline personality with self-harm

CAMS (Collaborative Assessment and Management of Suicidality)

CCS pearl: On CCS, for a discharged ED patient with passive ideation and no plan, the order set should include: "safety plan completed and given to patient," "lethal means counseling documented," "follow-up scheduled within 48–72 hours," "988 number provided," and "outpatient psychiatry referral." Missing any of these can lower the score.

Lethal means counseling (LMC) specifics
Crisis services
Inpatient unit safety protocols
Post-attempt psychotherapies with evidence
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Special Populations — Elderly and Medically Ill

Highest completion rates in US: men ≥75 (suicide rate 3–4× general population)

— More planning, more lethal means (firearms predominate), fewer prior attempts, fewer warnings

— Often present with physical complaints, not psychiatric — somatic depression, insomnia, weight loss

— Underdiagnosed because primary care visits focus on medical comorbidities

— Recent widowhood (highest risk in first year, particularly widowers)

— Functional decline, loss of independence, fall, new diagnosis of dementia or terminal illness

— Chronic pain (back, headache, GI)

— Social isolation, financial strain

— Polypharmacy, alcohol use, sedative-hypnotics

Hopelessness more predictive than depression severity in elderly

— Use Geriatric Depression Scale (GDS) rather than PHQ-9 (validated for older adults, less somatic-item burden)

— SSRIs first-line: sertraline, escitalopram preferred; start low (12.5–25 mg sertraline), titrate slow

— Avoid paroxetine (anticholinergic), citalopram >20 mg (QTc), TCAs, benzodiazepines (falls, delirium)

— Monitor for SIADH/hyponatremia with SSRIs in elderly — check Na at 2–4 weeks

— Consider ECT — well-tolerated and effective in geriatric depression with suicidality

— Higher suicide risk: cancer (first year post-diagnosis, especially lung, head/neck, pancreatic), HIV, MS, Huntington, ESRD on dialysis, COPD, chronic pain, TBI

Steroids, interferon, varenicline (boxed warning removed but still monitor), isotretinoin, levetiracetam — drug-induced mood changes

— Address pain control adequately — poorly controlled pain is a modifiable risk factor

Key distinction: Medical Aid in Dying (MAID) in states where legal is distinct from suicide — requires terminal illness with prognosis <6 months, capacity, voluntary repeated requests, and physician oversight. A patient requesting MAID still warrants assessment for treatable depression, which can mimic terminal hopelessness.

Geriatric suicide — high lethality, low warning
Risk factors specific to elderly
Screening and management
Medically ill patients
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Special Populations — Adolescents, Pregnancy, and LGBTQ+

— Suicide is the 2nd leading cause of death ages 10–24

— Screen with ASQ (4 items, validated in pediatric ED) or PHQ-A

— Risk factors: bullying (in-person and cyber), LGBTQ+ identity without family support, recent breakup, academic failure, social media exposure (suicide contagion), prior NSSI, ADHD, conduct disorder

Confidentiality limits: most states allow adolescents to consent to mental health care, but suicide risk overrides confidentiality — parents must be informed for safety planning and means restriction

— Firearm in home → ALWAYS counsel parents on storage; single greatest pediatric suicide intervention

Fluoxetine — FDA-approved for MDD ages 8+

Escitalopram — FDA-approved for MDD ages 12+

— Both fluoxetine and sertraline approved for pediatric OCD

— Black box warning highest relevance in this age group — monitor weekly initially

— CBT alone or in combination has the best evidence; TADS trial showed fluoxetine + CBT superior to either alone

— Suicide is a leading cause of maternal death in the first postpartum year (especially months 6–12)

— Screen with Edinburgh Postnatal Depression Scale (EPDS) — item 10 addresses self-harm

— Postpartum psychosis (rapid onset, 1–2 weeks postpartum) is a psychiatric emergency — high infanticide/suicide risk

Sertraline preferred SSRI in pregnancy and breastfeeding (minimal milk transfer); avoid paroxetine (cardiac malformations) and valproate (neural tube defects, lowest IQ outcomes)

— ECT safe in all trimesters and postpartum; lithium pregnancy risk (Ebstein anomaly) is lower than historically taught — case-by-case

— Transgender youth have markedly elevated rates of attempts (~40% lifetime in some surveys)

— Family acceptance and gender-affirming care are protective

— Avoid invalidating language; use chosen name and pronouns in chart

Board pearl: A postpartum mother with delusions about her infant being evil or possessed has postpartum psychosis until proven otherwise — admit, do not discharge home with the baby, even if she denies intent to harm. This is a Step 3 fail-safe answer.

Adolescents and young adults
Pediatric pharmacology
Perinatal suicide
LGBTQ+ patients
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Complications and Adverse Outcomes

Overdose: hepatotoxicity (APAP), arrhythmia (TCA, methadone, citalopram), serotonin syndrome (SSRI/MAOI/MDMA), anion gap acidosis (salicylates, toxic alcohols), aspiration pneumonia, rhabdomyolysis, compartment syndrome from prolonged immobility

Hanging: anoxic brain injury, cervical fracture (rare in low-drop), laryngeal injury, post-hanging pulmonary edema, ARDS, carotid dissection

Firearm: TBI with poor neurologic outcome, facial reconstruction, chronic disability

Jumping: polytrauma, calcaneal fracture pattern, vertebral burst fractures, pelvic injury, solid organ injury

Wrist cutting: tendon/nerve injury, infection; rarely lethal from blood loss alone (used more for NSSI)

Carbon monoxide: anoxic brain injury, delayed neurologic sequelae (2–6 weeks), cardiac ischemia — hyperbaric O₂ for severe cases

Recurrent attempts — 1-year reattempt rate ~15%; 10-year suicide death rate ~5% in attempters

— Worsening hopelessness post-failed attempt

— Survivor guilt, PTSD from attempt itself, identity changes

— Family/witness trauma

Boarding in ED — psychiatric patients wait hours-days for inpatient beds; risk of clinical deterioration, elopement, in-ED suicide

Restraint-related injury (chemical or physical) — use least restrictive

Medication errors — abrupt discontinuation of lithium triggers manic relapse; rebound depression with abrupt SSRI stop

Premature discharge — 30-day post-discharge suicide rate is 100× general population

— Inpatient suicide is a Joint Commission Sentinel Event — requires root cause analysis and corrective action plan

— Outpatient suicide of recently discharged patient often reviewed similarly

Step 3 management: After any failed attempt, the focus shifts from "Did they really mean it?" (irrelevant — outcome bias) to "What is the risk now, and what changes for treatment?" A medically minor attempt (small ingestion) with high intent and low rescue probability is higher risk than a medically severe attempt that was impulsive with high rescue probability.

Medical complications of attempts
Psychiatric complications
Iatrogenic and systems complications
Sentinel event reporting
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When to Escalate — ICU, Consultation, and Inpatient Triage

— Hemodynamic instability, vasopressor need

— Intubated/airway concern (CNS depression, aspiration, hanging-related laryngeal edema)

— Severe acidosis, hyperkalemia, ongoing arrhythmia

— TCA overdose with widened QRS, requiring sodium bicarbonate

— Severe APAP overdose on NAC with rising LFTs/INR (transplant eval threshold: King's College criteria)

— Salicylate level >100 mg/dL or AMS requiring HD

— Lithium >4 mEq/L or AMS — hemodialysis indicated

— Severe anoxic brain injury post-hanging or CO

— TCA, methadone, citalopram, hydroxychloroquine ingestion with QTc/QRS monitoring × 24 h

— Hemodynamically stable but requires close cardiac/neuro monitoring

— Medical issues requiring admission (e.g., hepatotoxicity trending, electrolytes) with active suicidal ideation

— Continuous 1:1 observation; psychiatry consult; environmental safety (no cords, ligature points)

— All intentional overdoses and attempts (before any disposition, even if "feels better now")

— New suicidal ideation in any admitted patient

— Capacity questions related to refusal of psychiatric care

— Postpartum psychosis suspicion

— Catatonia, severe agitation, ECT consideration

— Once medically cleared → transfer to psychiatric unit

— "Medical clearance" is not a checkbox — requires stable vitals, normal mental status (no delirium), addressed acute medical issues, and a psychiatrically-appropriate environment for ongoing care

— Acceptance to receiving facility before transfer

— EMTALA compliance — cannot refuse transfer/admission for inability to pay

— Maintain 1:1 during transport

CCS pearl: On CCS, before transferring a patient from medical ED to inpatient psychiatry, your order set must include: "medical clearance documented," "labs reviewed and stable," "psychiatry consult agrees with disposition," "1:1 sitter continued during transport," and "belongings searched." Skipping medical clearance and sending an unstable patient is a major safety lapse.

ICU admission criteria post-attempt
Stepdown / telemetry
Medical floor with sitter
Psychiatric consultation triggers
Inpatient psychiatry vs medical floor
Transfer considerations
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Key Differentials — Within Psychiatric Conditions

— Bipolar depression carries higher lifetime suicide risk (~15% vs ~6% in unipolar)

— Screen for past hypomania/mania (MDQ) before starting antidepressant monotherapy — can trigger mania or mixed states (highest suicide risk state)

— Mixed features (depression + agitation, racing thoughts) — high suicide risk; treat with mood stabilizer

— Chronic suicidality with frequent NSSI and low-lethality attempts; lifetime completion ~10%

— Repeated brief admissions can be iatrogenically harmful — reinforce hospitalization-seeking

— Best evidence: outpatient DBT, mentalization-based therapy, transference-focused therapy

— Admit for acute change in chronic pattern, not chronic ideation alone

— ~5% lifetime suicide rate; highest risk early in illness, after psychotic episode, with insight return, with comorbid depression

— Command hallucinations elevate acute risk

Clozapine uniquely reduces suicide

— Elevated suicide risk; comorbid depression, SUD, TBI common

— Veterans: 988 → press 1 for Veterans Crisis Line; VA safety planning standard

— Alcohol use disorder: 60–120× general population suicide risk

— Acute intoxication disinhibits and impairs judgment — reassess after sobriety before disposition decisions

— Opioid use disorder + benzodiazepine combinations — often unclear if overdose was intentional

— Anorexia nervosa has the highest mortality of any psychiatric disorder — half from suicide

— Address both medical instability (refeeding, electrolytes) and psychiatric risk

Key distinction: Chronic suicidal ideation in borderline personality (baseline) vs acute exacerbation requires careful assessment — admit for new specific plan, recent severe attempt, loss of outpatient support, comorbid acute depression, not chronic ideation alone. Over-hospitalization in BPD worsens long-term outcomes.

Major depressive disorder vs bipolar depression
Borderline personality disorder
Schizophrenia and schizoaffective disorder
PTSD
Substance use disorders
Eating disorders
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Key Differentials — Medical Mimics and Drug-Induced Causes

Hypothyroidism — fatigue, depression, cognitive slowing; check TSH

Hypercalcemia — depression, constipation, polyuria; check Ca, PTH

Cushing syndrome — depression in 50%+; consider in unexplained depression with hypertension, central obesity, striae

Addison disease — fatigue, depression, hyponatremia, hyperpigmentation

B12/folate deficiency — depression, cognitive changes, neuropathy

Vitamin D deficiency — modest contribution

HIV — direct CNS effects and reactive depression

Neurosyphilis — neuropsychiatric presentation

Wilson disease — young adult with mood/psychotic symptoms + hepatic/neurologic findings; check ceruloplasmin

Huntington disease — high suicide rate, particularly around diagnosis and loss of independence

TBI — even mild TBI elevates suicide risk; screen all TBI patients

Sleep apnea, chronic insomnia — insomnia is an independent suicide risk factor

Corticosteroids — dose-related; mania, depression, psychosis

Interferon-α — depression, suicidality; screen before and during

Isotretinoin — controversial but black box; counsel and monitor

Levetiracetam — irritability, depression in ~10%

β-blockers — historically implicated; modest effect

Varenicline — original boxed warning removed (EAGLES trial); still monitor

Mefloquine — neuropsychiatric effects, contraindicated with psychiatric history

Withdrawal states: alcohol, benzodiazepines, opioids — all increase acute suicide risk

Akathisia from antipsychotics/SSRIs — agitated dysphoria misread as worsening depression; treat with propranolol or benztropine, reduce offending agent

— Acute confusion can manifest as agitated, paranoid, or hopeless behavior; suicide attempts during delirium are documented

— Address underlying cause (infection, metabolic, drug-induced) before attributing to primary psychiatric illness

Board pearl: A new "depression" in a previously healthy older adult with weight loss, unexplained anemia, or constitutional symptoms requires a medical workup first — occult malignancy (pancreatic cancer classically presents with depression preceding diagnosis) is a Step 3 favorite.

Medical conditions presenting as depression/suicidality
Drug-induced mood/suicidality
Delirium
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Secondary Prevention and Discharge Planning

Written safety plan in patient's hands at discharge (Stanley-Brown)

Lethal means restriction documented with specific plan (firearms off-site, meds locked/dispensed)

Caring contacts — brief follow-up letters/texts/calls for weeks-months post-discharge (Motto/Luxton evidence base)

Bridge appointment within 7 days of discharge — ideally within 24–72 h for high-risk

Warm handoff — direct introduction to outpatient provider, not just a phone number

988 and crisis resources written, with patient demonstrating knowledge of how to use

— Continue effective acute treatment (lithium, clozapine, antidepressant) — do not abruptly discontinue

— Dispense limited quantities of high-lethality medications (TCAs, lithium narrow therapeutic index)

— Address insomnia aggressively — insomnia is a modifiable suicide risk factor (CBT-I preferred over benzodiazepines)

— Treat comorbid SUD — refer to MAT (buprenorphine, naltrexone, acamprosate)

CT-SP (Brown/Wenzel) — 10 sessions, 50% reduction in reattempts

DBT — for BPD with chronic suicidality

CAMS — collaborative outpatient framework

IPT, CBT, problem-solving therapy — for underlying mood disorders

— Connect to peer support (NAMI, AA/NA, suicide attempt survivor groups)

— Address social determinants: housing, food, financial counseling

— Employer FMLA paperwork, school accommodations

— Faith community involvement if patient-aligned

— Warning signs to monitor

— How to remove/secure means

— How to use 988, mobile crisis, ED

— Self-care for caregivers — burnout is real

Step 3 management: The 30 days post-discharge is the highest-risk period — schedule the first follow-up within 7 days (ideally 48–72 h), and use caring contacts (a brief check-in text, call, or letter) — these alone reduce reattempts in RCTs. "Follow up in 4–6 weeks" is the wrong answer post-discharge.

Discharge bundle (evidence-based, reduces post-discharge suicide)
Medication management post-discharge
Ongoing psychotherapy referrals
Social and systems interventions
Family/caregiver education
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Follow-Up Cadence and Monitoring

Day 1–3: phone or in-person contact, confirm safety plan in use, medication adherence, side effects, ideation status

Day 7: in-person bridge visit (psychiatry or PCP), reassess C-SSRS, refine safety plan

Day 14: PHQ-9, GAD-7, medication titration

Day 30: comprehensive reassessment, transition to standard cadence if stable

— Every 2–4 weeks during medication initiation/titration

— Every 4–6 weeks during stabilization

— Every 3 months during maintenance

— PHQ-9 + suicide item (PHQ-9 item 9 or C-SSRS) at every visit

Lithium: level (5–7 days after change, then q3 mo), TSH, Cr q6–12 mo, Ca q12 mo

Valproate: level, LFTs, CBC, weight

Clozapine: ANC weekly × 6 mo, q2 weeks × 6 mo, then monthly; metabolic monitoring; myocarditis risk first 4 weeks

SSRIs: Na at 2–4 weeks in elderly; QTc with citalopram

ECT: cognitive screening, anesthesia tolerance

— PHQ-9 score trajectory

— Functional measures (work, school, relationships, sleep, appetite)

— Repeat C-SSRS

— Therapy engagement and homework adherence

— Substance use status

— Worsening PHQ-9 item 9

— Increased alcohol/substance use

— Sleep disturbance

— New psychosocial stressor

— Medication non-adherence

— Treatment dropout — proactive outreach when patient misses appointment

— Anniversary reactions (loss anniversaries, prior attempt anniversaries)

— Seasonal patterns (peak completed suicides spring/early summer, not winter as myth suggests)

— Transition points: graduation, retirement, deaths, divorces

CCS pearl: On CCS for a recently discharged suicidal patient, your follow-up clock should advance in days, not weeks — "follow up in 3 days" and "telephone check-in tomorrow" beat "follow up in 1 month" every time. Re-administer PHQ-9 and C-SSRS at each visit and document.

First 30 days post-discharge or post-crisis
Standard outpatient cadence (stable)
Medication monitoring
Outcome metrics
Relapse signals to act on
Long-term considerations
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Ethical, Legal, and Patient Safety Considerations

— Suicide risk overrides confidentiality for safety — disclose to family/emergency contacts as needed to ensure safety, lethal means restriction, and follow-through

Tarasoff duty (in most states): duty to warn/protect identifiable third parties if patient poses serious threat — applies to homicidal more than suicidal ideation, but parallel safety duty applies

— Adolescents: confidentiality is conditionally protected but suicide risk requires parental involvement

— Documentation: note what was disclosed, to whom, and the safety rationale

— Capacity is decision- and time-specific

— Patients with severe depression often retain capacity but may have impaired judgment due to hopelessness — careful assessment required

Involuntary hold criteria (state-specific but common elements):

— Mental illness present

— Imminent danger to self or others, OR grave disability

— Less restrictive alternative not available

— Holds are time-limited (typically 72 hours); continued involuntary treatment requires judicial review

— A suicidal patient can refuse medical treatment (e.g., refuse NAC for APAP overdose) if they retain capacity — but suicidal intent itself raises capacity concerns and may justify emergency treatment under implied consent

— In practice: provide life-saving medical treatment first; address psychiatric refusal afterward

— Document capacity assessment carefully

Firearm-related self-injury may have state-specific reporting requirements

— Suspected abuse contributing to suicidality (child, elder, vulnerable adult) — mandatory reporting

— Workplace/school threats — duty to warn may extend

— Discharge from inpatient psychiatry without scheduled outpatient follow-up = major safety lapse

— Handoff to outpatient must include: diagnoses, current meds, suicide risk formulation, safety plan, means restriction status, follow-up scheduled

— Use the post-discharge safety bundle: caring contacts, 7-day appointment, warm handoff

— Postvention: peer support, M&M review, root cause analysis

— Avoid defensive practice changes that harm other patients

— Self-care; ~50% of psychiatrists experience a patient suicide in career

Board pearl: Documentation that contains a risk formulation ("Risk is intermediate acute / chronic high because…") and an explicit rationale for disposition is the single best protection — both for patients and against malpractice claims. "Denies SI" alone in a charting note is insufficient.

Confidentiality limits
Capacity and involuntary care
Informed consent edge cases
Mandatory reporting and documentation
Transition-of-care safety (Step 3 favorite)
Provider after a patient suicide
Solid White Background
High-Yield Associations and Rapid-Fire Facts

— Highest US suicide rate: non-Hispanic white men age 75+

— Highest attempt rate: young women; highest completion rate: older men

— Method by sex: men → firearms; women → poisoning (but firearms rising)

— Firearms: 50% of US deaths, ~85% case fatality

— AI/AN populations: highest rates by ethnicity, particularly youth

— LGBTQ+ youth: 4× increased attempt rate; transgender youth higher still

— Veterans: ~1.5× general population; 988 → press 1

Prior attempt (5–6× risk)

Hopelessness (strongest cognitive predictor)

Access to lethal means, especially firearms

Recent discharge from psychiatric hospitalization (first 30–90 days)

Acute intoxication at time of crisis

Lithium — mood disorders

Clozapine — schizophrenia (FDA-approved indication)

Ketamine/esketamine — rapid SI reduction

ECT — fastest for severe depression with active SI

— TCAs (amitriptyline most lethal)

— MAOIs

— Lithium (narrow therapeutic index) — but benefits often outweigh; dispense limited quantities

— Opioids, benzodiazepines (combined respiratory depression)

PHQ-9 (screen)

C-SSRS (stratify)

ASQ (pediatric ED screen)

GDS (geriatric)

EPDS (perinatal)

Stanley-Brown Safety Plan (intervention)

988 Suicide & Crisis Lifeline (resource)

— "Asking about suicide plants the idea" — FALSE

— "People who talk about it don't do it" — FALSE

— "No-suicide contracts work" — FALSE; replaced by safety planning

— "Most suicides happen in winter holidays" — FALSE; peak spring/early summer

— "Improved mood means crisis resolved" — sometimes ominous

— TJC: screen all medical/surgical inpatients with primary behavioral health complaint

— USPSTF (2023): screen adults and adolescents 12+ for depression; insufficient evidence to screen general adult population for suicide risk specifically — but act on positive depression screens

Step 3 management: Memorize the post-discharge bundle: 7-day follow-up + caring contacts + safety plan + means restriction + 988 — these together reduce 30-day reattempts in multiple RCTs and are the highest-yield "next best step" answers.

Epidemiology
Strongest predictors
Medications with anti-suicide evidence
Medications to avoid in suicidal patients (overdose lethality)
Tools to know
Myths to reject
Joint Commission/USPSTF
Solid White Background
Board Question Stem Patterns

— 24F brought in after ingesting 30 acetaminophen tablets 6 hours ago, says "I just wanted the pain to stop." Vitals stable. APAP level pending.

Best initial action: check APAP level at 4-hr mark, plot on Rumack-Matthew; if above treatment line → start NAC; obtain salicylate, ethanol, UDS; 1:1 sitter; psychiatric consult after medical stabilization; do not discharge before psychiatric eval

— 45M at annual physical, PHQ-9 = 18, item 9 = "more than half the days"

Next step: structured suicide assessment (C-SSRS), specifically ask about plan/intent/means/firearm access; safety plan; lethal means counseling; start SSRI (sertraline/escitalopram); follow-up in 1–2 weeks; not "refer to psychiatry in 4–6 weeks alone"

— 30F discharged from inpatient psych 5 days ago after suicide attempt, calls saying she stopped her lithium because of weight gain

Next step: same-day or next-day appointment, reassess SI with C-SSRS, address med side effect (consider alternative or adjunct), reinforce safety plan, verify firearm/med restriction; 30-day post-discharge is highest-risk window

— 16M with cuts on forearm, tells school counselor "I've thought about killing myself"; parents called to ED

Best action: full assessment with patient and collateral with parents; firearm access query (mandatory); admit if active plan/intent or unable to ensure safety at home; fluoxetine + CBT for moderate-severe MDD; weekly follow-up initially; do not rely on confidentiality alone

— 78M widowed 4 months ago, recent weight loss, somatic complaints, lives alone with rifle for "protection"

Best action: GDS or PHQ-9; direct SI inquiry; firearm removal with family member (highest-yield intervention); SSRI (sertraline 25 mg start); same-week follow-up; consider home visit/social work

— 28F on sertraline for "depression," now agitated, not sleeping, racing thoughts, with new suicidal ideation

Best action: stop SSRI (likely activated mixed state in undiagnosed bipolar); admit; mood stabilizer (lithium or valproate) ± antipsychotic; reassess diagnosis with MDQ; mixed states = highest suicide risk

— Patient with active SI and plan refuses admission, has capacity for most decisions

Best action: involuntary hold (state-specific name) — danger to self due to mental illness; document capacity assessment, less-restrictive alternatives considered

Board pearl: When stems offer "no-suicide contract" or "follow up in 4–6 weeks" as options after a positive screen or recent attempt, those are distractors. The correct answer is always structured safety plan + lethal means counseling + close follow-up (≤7 days).

Stem 1: ED post-overdose
Stem 2: Outpatient PHQ-9 positive item 9
Stem 3: Recent discharge
Stem 4: Adolescent
Stem 5: Geriatric
Stem 6: Bipolar mixed features
Stem 7: Ethics/disposition
Solid White Background
One-Line Recap

Suicide risk assessment is a structured clinical formulation — not a checklist — that integrates static and dynamic risk with protective factors to guide disposition, and is paired with a Stanley-Brown safety plan, lethal means restriction (especially firearms), and close post-crisis follow-up to reduce death.

Direct assessment: C-SSRS-style inquiry into ideation, plan, intent, means, prior attempts, hopelessness

Means restriction: firearm and medication access counseled with a specific, named plan; documented

Safety planning: Stanley-Brown 6-step plan, written, in patient's hands; no-suicide contracts are not acceptable substitutes

Follow-up: 24–72 h for high-intermediate risk; ≤7 days post-discharge; caring contacts reduce reattempts

Lithium (mood disorders)

Clozapine (schizophrenia — FDA-approved for suicide reduction)

Ketamine/esketamine (rapid acute ideation reduction); ECT as definitive treatment for severe depression with active SI

Older men with firearms post-loss — highest completion rates, fewest warnings

Postpartum mothers with new psychosis or worsening depression — suicide is a leading maternal mortality cause

Recently discharged psychiatric patients in the first 30 days — 100× general-population risk

Restricting access to lethal means, especially firearms — the only intervention with consistent population-level evidence to reduce suicide mortality, and the highest-yield Step 3 answer when offered alongside generic options like "schedule follow-up" or "start SSRI"

Step 3 management: When in doubt on exam — ask directly about SI, assess plan/intent/means, restrict means (firearms off-site), build a safety plan, schedule follow-up within days, and treat the underlying disorder. That sequence wins almost every suicide-risk vignette.

The four non-negotiables at every encounter with suicidal ideation
The three medications with anti-suicide evidence
The three populations not to miss
The single most important systems intervention
Solid White Background
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