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Iron Overload Disorders — Secondary Hemochromatosis (Transfusion-Related)

A 42-year-old woman with beta-thalassemia major has received >50 transfusions. She has diabetes, bronze skin, and hepatomegaly. Ferritin 2500 ng/mL, MRI liver iron elevated.

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💡 Hint: Correct order adjusted to match available steps.

Monitor ferritin and MRI liver iron concentration

Consider HSCT in eligible thalassemia patients

Avoid phlebotomy in transfusion-dependent anemia

Monitor cardiac MRI T2*, endocrine labs

Start iron chelation therapy (deferasirox, deferoxamine, deferiprone)

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