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QT Prolongation & Torsades Risk — Polypharmacy

A 76-year-old man with COPD and depression presents with syncope. Meds: citalopram 40 mg, azithromycin 5-day pack, ondansetron PRN, furosemide. ECG QTc 510 ms, K 3.2, Mg 1.6.

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Replete K to >4.5 and Mg to >2.0; treat hypoxia

Pharmacy review of QT interactions; update EMR alerts

Continuous monitoring and avoid additional QT agents

Use alternatives (doxycycline instead of macrolide; lower-dose SSRI)

Hold QT-prolonging agents (macrolide, high-dose citalopram, ondansetron)

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