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Transitioning from Methadone to Buprenorphine

A 39-year-old man on methadone 60 mg daily for OUD wishes to transition to office-based buprenorphine. Outline diagnosis and management steps.

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Wait ≥36 hours since last methadone dose and onset of moderate withdrawal (COWS ≥8–12)

Start low-dose buprenorphine (2–4 mg), titrate as tolerated

Frequent follow-up for stabilization, cravings, and adherence

Counsel about precipitated withdrawal risk and provide close monitoring

Ensure methadone dose tapered to ≤30–40 mg/day; patient motivated for switch

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